Effects of Plasma Aldosterone and Renin Concentrations With Blood Pressure Variation and Hypertension Risk in Chinese Adults: A Population-Based Hakka Biobank Study
Authors' conclusion
Higher PAC and ARR, lower PRC were associated with adverse BP variation and elevated risk of hypertension, especially among participants in the context of renin suppression or autonomous aldosterone secretion.
Study context
- Population
- Adults from the Hakka Biobank cohort of China
- Participants
- 8,914 adults
- Exposure
- Associations of plasma aldosterone concentration (PAC), plasma renin concentration (PRC) and aldosterone-to-renin ratio (ARR) with blood pressure (BP)-related phenotypes
- Outcome
- Associations of log-PAC, log-PRC and log-ARR with BP phenotypes and hypertension
Methodological detailsregression models, restricted cubic spline, subgroup analyses
- Regression models
- Restricted cubic spline
- Subgroup analyses
Main finding
As reported in the abstract
- Higher log-PAC and log-ARR, and lower log-PRC, associated with higher systolic BP, diastolic BP, pulse pressure and mean arterial pressure
- all P < .001
- OR per 1-unit higher log-PAC or lower log-PRC for systolic, diastolic, clinic and systolic-diastolic hypertension, lowest
- 1.67 (95% CI, 1.47-1.85)
- OR per 1-unit higher log-PAC or lower log-PRC for systolic, diastolic, clinic and systolic-diastolic hypertension, highest
- 6.29 (95% CI, 4.48-8.83)
- OR of higher log-ARR for systolic-diastolic hypertension
- 1.66 (95% CI, 1.47-1.86)
- OR of higher log-ARR for clinic hypertension
- 2.42 (95% CI, 2.14-2.73)
Observational data: associations, not effects.
Further findings
Subgroup, sensitivity analyses and renin-independent aldosteronism vs normal aldosterone or renin-dependent aldosteronism
- Consistent associations
- all P < .05
Nonlinearity of associations of log-PAC, log-PRC and log-ARR with hypertension
- Significant nonlinear associations (restricted cubic spline)
- all P nonlinearity < 0.05
Original publication
Effects of Plasma Aldosterone and Renin Concentrations With Blood Pressure Variation and Hypertension Risk in Chinese Adults: A Population-Based Hakka Biobank Study. Endocr Pract. Published 25 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →