Effects of Subclinical Hypothyroidism on Nephropathy Complicating Type 2 Diabetes: The Fremantle Diabetes Study Phase II
Authors' conclusion
Persistent SCH/overt hypothyroidism was associated with incident increased albuminuria not observed in euthyroid participants. Assessment of thyroid function in all patients with T2DM may be indicated, as some previous studies provide evidence that thyroxine replacement may ameliorate albuminuria.
Study context
- Population
- Urban community-dwelling people with T2D in the Fremantle Diabetes Study Phase II, without known thyroid dysfunction at baseline and follow-up
- Participants
- 725 people
- Exposure
- Persistent vs transient subclinical hypothyroidism (SCH)/overt hypothyroidism vs stable euthyroidism
- Euthyroidismn = 683reference
- Transient SCH/overt hypothyroidismn = 18
- Persistent SCH/overt hypothyroidismn = 24
- Outcome
- Changes in eGFR and urine albumin:creatinine ratio (ACR) by thyroid status
- Follow-up
- Mean ± SD 4.3 ± 0.4 years
Methodological detailsprospective, community-based
- Prospective
- Community-based
Main finding
As reported in the abstract
ΔACR · mean 4.3 years
Persistent SCH/overt hypothyroidism
22.0
mean · SD 81.4 · mg/mmol
Euthyroidism
0.4
mean · SD 36.7 · mg/mmol
Transient SCH/overt hypothyroidism
−0.3
mean · SD 5.7 · mg/mmol
P = 0.027
Observational data: associations, not effects.
Further findings
ΔACR excluding baseline albumin:creatinine ratio (ACR) > 30 mg/mmol
- Similar results
Original publication
Effects of Subclinical Hypothyroidism on Nephropathy Complicating Type 2 Diabetes: The Fremantle Diabetes Study Phase II. J Clin Endocrinol Metab. Published 29 August 2025. doi:10.
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