Effects of Maternal Exercise Modes on Glucose and Lipid Metabolism in Offspring Stem Cells
Authors' conclusion
Our data demonstrates that maternal exercise enhances glucose and lipid metabolism of offspring MSCs. Improvements in MSC glucose metabolism seem to be the greatest with maternal RE. Clinical Trial:
Study context
- Population
- Healthy females aged 18–35 years, <16 weeks' gestation; clinical research facility
- Comparison
- Maternal aerobic, resistance (RE) or combination exercise vs non-exercising control
- Primary endpoint
- Offspring umbilical cord MSC glucose and fatty acid metabolism, assessed with radiolabeled substrates
- Follow-up
- At delivery
Primary result
As reported in the abstract
- Greater partitioning of oleate toward complete oxidation in mesenchymal stem cell (MSCs) from all exercising groups vs non-exercisers
- P ≤ 0.05
- Greater partitioning of palmitate toward complete oxidation in MSCs from all exercising groups vs non-exercisers
- P ≤ 0.05
- Lower rates of incomplete fatty acid oxidation in MSCs from all exercising groups, related to infant adiposity at 1 month
- P ≤ 0.05
- Higher insulin-stimulated glycogen synthesis rates in MSCs from all exercising groups, RE having the largest effect
- P ≤ 0.05
- RE had the greatest effect on MSC glucose oxidation rates
- P ≤ 0.05
- RE had the greatest effect on MSC partitioning toward complete glucose oxidation
- P ≤ 0.05
Original publication
Effects of Maternal Exercise Modes on Glucose and Lipid Metabolism in Offspring Stem Cells. J Clin Endocrinol Metab. Published 1 February 2023. doi:10.
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