Effects of intermittent or single high-dose vitamin D supplementation on risk of falls and fractures: a systematic review and meta-analysis
Authors' conclusion
Intermittent or single high-dose vitamin D supplementation had no preventive effect on the risk of falls and fractures and might even increase the risk of falls.
Study context
- Population
- Adults in randomized controlled trials (RCTs) of intermittent or single high-dose vitamin D supplementation; PubMed, EMBASE and Cochrane Library searched to May 25, 202215 RCTs
- Comparison
- Intermittent or single high-dose vitamin D supplementation vs control
- Outcome
- Falls and fractures (pooled RR)
Methodological detailsrandom-effects meta-analysis
- Random-effects meta-analysis
Pooled result
As reported in the abstract
High-dose vitamin DRelative risk (95% CI)
Falls; I2 = 56.6%; n = 11 RCTs
1.03(0.98–1.09)
Fractures; I2 = 48.3%; n = 11 RCTs
0.99(0.87–1.14)
Further pooled results
Fractures, RCTs with <1000 participants (subgroup)
| RR (95% CI) | ||
|---|---|---|
| High-dose vitamin DI2 = 0.0%; n = 5 RCTs | 0.74 (0.57–0.96) | |
| 0.512Relative risk (log scale) |
Fractures, RCTs with ≥1000 participants (subgroup)
| RR (95% CI) | ||
|---|---|---|
| High-dose vitamin DI2 = 57.5%; n = 6 RCTs | 1.06 (0.92–1.21) | |
| 0.512Relative risk (log scale) |
Falls, high-dose vitamin D3 (subgroup)
| RR (95% CI) | P value | ||
|---|---|---|---|
| High-dose vitamin DVitamin D3; borderline significance; I2 = 50.0%; n = 7 RCTs | 1.06 (0.99–1.15) | P = 0.051 | |
| 0.512Relative risk (log scale) |
Original publication
Effects of intermittent or single high-dose vitamin D supplementation on risk of falls and fractures: a systematic review and meta-analysis. Osteoporos Int. Published 29 April 2023. doi:10.
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