Effects of High‐Protein Diets on Renal Function and Body Composition in Adults Without Chronic Kidney Disease: A Systematic Review and Meta‐Analysis of Randomised Trials
Authors' conclusion
High-protein diets were associated with increases in eGFR without consistent biochemical evidence of renal injury in adults without chronic kidney disease.
Study context
- Population
- Adults without CKD; RCTs from PubMed, Embase and Cochrane CENTRAL, inception to May 202622 RCTs
- Comparison
- High-protein diets vs normal- or low-protein diets
- Outcome
- eGFR and serum creatinine
Methodological detailsrandom-effects meta-analysis, restricted maximum likelihood estimation, Cochrane RoB 2, GRADE
- Random-effects meta-analysis
- Restricted maximum likelihood estimation
- Cochrane RoB 2
- GRADE
Pooled result
As reported in the abstract
High-protein diets vs NPL dietsEstimate (95% CI)
I 2 = 74.9%
SMD (eGFR) 0.39(0.09–0.69)
19 trials; n = 1044; I 2 = 20.8%
SMD (serum creatinine) 0.08(−0.09 to 0.25)
Further pooled results
Body composition
- High-protein diets reduced body fat percentage and total fat mass
- No significant effect on fat-free mass
Original publication
Effects of High‐Protein Diets on Renal Function and Body Composition in Adults Without Chronic Kidney Disease: A Systematic Review and Meta‐Analysis of Randomised Trials. Diabetes Obes Metab. Published 14 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →