Effects of Continuous Glucose Monitoring on Impaired Awareness of Hypoglycemia in Older Adults With Type 1 Diabetes: A Post Hoc Analysis of the WISDM Study
Authors' conclusion
In older adults with type 1 diabetes, CGM improves hypoglycemia; however, its role in improving IAH is variable, depending on the scoring method. This study highlights the limitations of the Clarke score.
Study context
- Population
- Older adults with T1D using continuous glucose monitoring (CGM)
- Comparison
- Impaired awareness of hypoglycemia (IAH) scores at baseline vs 26 and 52 weeks of CGM use
- Primary endpoint
- IAH by Clarke original score (Clarke-full) and subscales Hypoglycemia Awareness Factor (HAF) and Severe Hypoglycemia Experienced Factors (SHEF)
- Follow-up
- Baseline, 26 weeks, and 52 weeks
Primary result
As reported in the abstract
IAH (Clarke scores) with CGM use · 26 and 52 weeks
- Clarke-SHEF decreased significantly after 26 weeks (n = 184)
- P = 0.02
- Clarke-SHEF decreased significantly after 52 weeks (n = 94)
- P < 0.0001
Further findings
IAH subgroup · 52 weeks
- Clarke-full but not Clarke-HAF improved in the IAH subgroup
Original publication
Effects of Continuous Glucose Monitoring on Impaired Awareness of Hypoglycemia in Older Adults With Type 1 Diabetes: A Post Hoc Analysis of the WISDM Study. Diabetes Care. Published 3 September 2025. doi:10.
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