Effectiveness of probiotic therapy as an adjunct in the management of periodontal disease in type 2 diabetics: A systematic review and meta-analysis
Pooled result · IL-6 levelsResult — go to the resultSMD −1.07 95% CI −1.91 to −0.24Authors' conclusion
Adjunctive probiotic therapy effectively reduces IL-6 levels and probing depth in patients with T2DM complicated by periodontal disease.
Study context
- Population
- People with both T2D and periodontal disease7 studies (5 randomized controlled trials (RCTs), 2 quasi-experimental studies (QERs))
- Participants
- 514 people
- Comparison
- Adjunctive probiotic therapy vs Non-Surgical Periodontal Treatment (NSPT) monotherapy
- Outcome
- IL-6 levels
Methodological detailsseven electronic databases searched to June 08, 2025, RoB 2 for RCTs; Joanna Briggs Institute (JBI) critical appraisal tool for QERs
- Seven electronic databases searched to June 08, 2025
- RoB 2 for RCTs; JBI critical appraisal tool for QERs
Pooled result
As reported in the abstract
SMD
−1.07
95% CI −1.91 to −0.24
P = 0.01
Adjunctive probiotic therapyvs NSPT monotherapy
SMD −1.07 (95% CI −1.91 to −0.24); P = 0.01
Further pooled results
| Outcome | SMD (95% CI) | P value | |
|---|---|---|---|
| Probing depth | −1.13 (−2.19 to −0.07) | P = 0.04 | |
| −3−2−101Difference (linear scale) |
Original publication
Effectiveness of probiotic therapy as an adjunct in the management of periodontal disease in type 2 diabetics: A systematic review and meta-analysis. Diabetes Res Clin Pract. Published 1 July 2025. doi:10.
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