Effectiveness and predictors of weight loss response to phentermine plus lifestyle modifications among youth in a paediatric weight management clinical setting
Authors' conclusion
Phentermine plus LSM reduced %BMIp95 among youth in a weight management clinic, and baseline characteristics may help determine those more or less likely to respond. Prospective studies are needed to further characterize effectiveness and confirm response predictors.
Study context
- Population
- Youth seen in a US academic-based weight management clinic, 2012–2020; mean %BMIp95 150%
- Participants
- 91 participants
- Outcome
- %BMIp95 change
- Follow-up
- 1.5, 3, 6 and 12 months
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Peak reduction at 6 months (p < 0.001)
10.9 percentage points
Observational data: associations, not effects.
Further findings
Predictors of response: baseline elevated ALT · 1.5 months
- Elevated baseline ALT associated with smaller 1.5-month %BMIp95 reductions (p = 0.001)
- Considering multiple comparisons
Predictors of response: higher food responsiveness · 3 and 6 months
- Higher food responsiveness associated with smaller 3-month (p = 0.001) and 6-month (p < 0.001) %BMIp95 reductions
- Considering multiple comparisons
Original publication
Effectiveness and predictors of weight loss response to phentermine plus lifestyle modifications among youth in a paediatric weight management clinical setting. Pediatr Obes. Published 17 June 2024. doi:10.
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