Obesity

Causality or confounding? Applying E values to examine associations between ultra-processed food consumption and risk of weight gain

Int J Obes (Lond)Published Systematic review and meta-analysis of prospective studies with E value analysis

Authors' conclusion

Unaccounted for confounding could plausibly explain the prospective association between UPF consumption and weight gain in adults. High quality observational research controlling for potential confounders and evidence from study types devoid of confounding are now needed.

Study context

Population
Adults in prospective studies on ultra-processed food (UPF) consumption and weight gain
Comparison
Higher vs lower UPF consumption
Outcome
Weight gain
Methodological detailsE value approach
  • E value approach

Pooled result

As reported in the abstract

Higher UPF consumption associated with increased weight gain in meta-analysis (RR)

1.14

E value; unaccounted confounders with small-to-moderate associations with UPF consumption and weight gain could hypothetically account for observed associations

1.55

Original publication

Causality or confounding? Applying E values to examine associations between ultra-processed food consumption and risk of weight gain. Int J Obes (Lond). Published 15 June 2024. doi:10.1038/s41366-024-01566-8

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