Effect of Time-Restricted Eating on β-Cell Function in Adults With Type 2 Diabetes
Primary result · ISSI-2Result — go to the resultIncrease +14.0 ± 39.2 %Authors' conclusion
TRE improved β-cell function and insulin resistance in overweight patients with early diabetes, accompanied by beneficial effects on adiposity.
Study context
- Population
- Overweight adults with early T2D (mean 2.9 years diabetes duration; baseline HbA1c 6.6% ± 0.7%; BMI 32.4 ± 5.7)
- Participants
- 39 adults
- Comparison
- Time-restricted eating vs standard lifestyle, 6 weeks
- Primary endpoint
- β-cell function by Insulin Secretion-Sensitivity Index-2 (ISSI-2) from an OGTT
- Follow-up
- 6 weeks
Primary result
ISSI-2
Increase
+14.0 ± 39.2 %
P = 0.03
As reported in the abstract
Further findings
| Outcome | Change (%) (CI) | P value | |
|---|---|---|---|
| Hepatic insulin resistance (HOMA-IR)14% reduction with TRE | −11.6 (−49.3 to 21.9) | P = 0.03 | |
| −60−40−2002040Difference, % (linear scale) |
| Outcome | Estimate | P value |
|---|---|---|
| HbA1c | reduction −0.32 ± 0.48 % | P < 0.001 |
| Body weight | reduction −3.86 ± 3.1 % | P < 0.001 |
| Waist circumference | reduction −3.8 ± 7.5 cm | P = 0.003 |
Fasting glucose
- Fasting glucose did not differ between interventions
Original publication
Effect of Time-Restricted Eating on β-Cell Function in Adults With Type 2 Diabetes. J Clin Endocrinol Metab. Published 28 August 2024. doi:10.
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