Effect of synbiotics on weight loss and metabolic health in adults with overweight and obesity: A randomized controlled trial
Authors' conclusion
The study demonstrates that synbiotic V5 and V7 were effective in reducing body weight in individuals with lifestyle modification.
Study context
- Population
- Adults aged 30 to 60 years with BMI 25 to 34.9 kg/m²
- Participants
- 172 adults
- Comparison
- Synbiotic V5 or V7 vs placebo
- Primary endpoint
- Change in BMI and body fat percentage
- Follow-up
- 12 weeks
Methodological detailsdouble-blind, placebo-controlled
- Double-blind
- Placebo-controlled
Primary result
As reported in the abstract
Change in BMI · baseline to end of study
- Significant reduction in BMI from baseline in V5 and V7
- p < 0.0001
- Nonsignificant change in BMI in placebo
- p = 0.0711
Secondary outcomes
| Outcome | P value |
|---|---|
| HDL-C increaseV5 vs Placebo · significant increase vs placebo | P < 0.0001 |
| HDL-C increaseV7 vs Placebo · significant increase vs placebo | P = 0.0205 |
| High-sensitivity C-reactive protein decreaseV5 vs Placebo · significant decrease | P < 0.0001 |
| High-sensitivity C-reactive protein decreaseV7 vs Placebo · significant decrease | 0.0005 |
Body weight
- Decrease in body weight with V5 and V7
- P < 0.0001
Original publication
Effect of synbiotics on weight loss and metabolic health in adults with overweight and obesity: A randomized controlled trial. Obesity (Silver Spring). Published 9 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →