Endocrine oncology

Effect of Radioactive Iodine Therapy on Cancer-Specific Survival of Papillary Thyroid Cancer Tall Cell Variant

J Clin Endocrinol MetabPublished Retrospective cohort study

Main finding · CSSResult — go to the resultHazard ratio 0.54 95% CI 0.25–1.17

Authors' conclusion

RAI therapy may not improve CSS in patients with TCV-PTC after total thyroidectomy. Future studies with larger sample sizes, longer follow-up periods, and better study designs are needed to confirm or refine our research findings.

Study context

Population
Patients with TCV-PTC who underwent total thyroidectomy, 2004–2019, SEER database
Participants
1,281 patients373 matched pairs
Exposure
Radioactive iodine (RAI) therapy vs no RAI therapy
Outcome
Cancer-specific survival (CSS)
Methodological detailspropensity-score matched, SEER database
  • Propensity-score matched
  • SEER database

Main finding

CSS

Hazard ratio

0.54

95% CI 0.25–1.17

P = 0.120

RAIvs Non-RAI
HR 0.54 (95% CI 0.25–1.17); P = 0.120

As reported in the abstract

Observational data: associations, not effects.

Further findings

Cancer-specific survival (CSS) in subgroups

Subgroup analyses indicated similar results

Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.

Original publication

Effect of Radioactive Iodine Therapy on Cancer-Specific Survival of Papillary Thyroid Cancer Tall Cell Variant. J Clin Endocrinol Metab. Published 7 October 2023. doi:10.1210/clinem/dgad580

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