Effect of Race/Ethnicity on United States FRAX Calculations and Treatment Qualification: A Registry-Based Study
Authors' conclusion
In summary, use of a single population-based FRAX calculator, rather than existing US race/ethnic FRAX calculators, will reduce differences in treatment qualification and may ultimately enhance equity and access to osteoporosis treatment.
Study context
- Population
- Women aged ≥50 years with self-reported race/ethnicity; FRAX treatment thresholds 3% hip fracture, 20% major osteoporotic fracture (MOF)
- Participants
- 114,942 / 485 / 2,816
- Exposure
- US race/ethnic FRAX calculators (White, Black, Asian, Hispanic) vs hypothetical single population-based FRAX calculator
- Whiten = 114,942reference
- Blackn = 485
- Asiann = 2,816
- Outcome
- FRAX scores exceeding hip fracture treatment threshold (3%)
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
FRAX scores exceeding MOF treatment threshold (20%)
Treatment qualification with additional criteria (fracture history, DXA T-score ≤−2.5)
- Disparities in treatment qualification were reduced
Non-White women recalculated with White FRAX calculator
- Mean values for Asian women slightly exceeded those for White women; for Black women remained substantially below White women
Single population-based FRAX calculator
- Mean fracture probability and treatment qualification increased for non-White women across the age range
Original publication
Effect of Race/Ethnicity on United States FRAX Calculations and Treatment Qualification: A Registry-Based Study. J Bone Miner Res. Published 10 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →