Effect of Helicobacter pylori on sleeve gastrectomy and gastric microbiome differences in patients with obesity and diabetes
Authors' conclusion
Therefore, these findings indicate that patients with obesity and diabetes clearly benefit from surgery, but H. pylori infection may also affect clinical improvement.
Study context
- Population
- Patients with obesity, diabetes mellitus (DM), and H. pylori infection undergoing sleeve gastrectomy
- Participants
- 40 patients
- Exposure
- Patients with obesity by DM and H. pylori status undergoing sleeve gastrectomy
- Outcome
- Clinical changes after sleeve gastrectomy
Methodological details16S V3-V4 sequencing
- 16S V3-V4 sequencing
Main finding
As reported in the abstract
- DM group: ALT, hemoglobin, HbA1c, blood glucose and HSI significantly decreased; HDL significantly increased
- H. pylori-positive group: no significant difference
Observational data: associations, not effects.
Further findings
Gastric microbiota diversity
- Diversity decreased in the order ND > DM > ND-HP > DM-HP
Correlation of preoperative microbes with clinical data
- ND-HP: most of top 20 gastric microbiota negatively correlated with glucose metabolism
- H. pylori infection positively correlated with pre-insulin levels
Original publication
Effect of Helicobacter pylori on sleeve gastrectomy and gastric microbiome differences in patients with obesity and diabetes. Int J Obes (Lond). Published 24 August 2024. doi:10.
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