Effect of Community-Based Integrated Care for Patients With Diabetes and Depression (CIC-PDD) in China: A Pragmatic Cluster-Randomized Trial
Primary result · Primary outcome, depressive symptoms component (≥50% reduction)Result — go to the resultRisk difference 31.03% 95% CI 21.85–40.21Authors' conclusion
The implementation strategy can serve as a valuable blueprint for the identification and treatment of patients with physical and mental multimorbidity in primary health care settings.
Study context
- Population
- Adults aged ≥18 years with T2D and depression (Patient Health Questionnaire-9 score ≥10), community health centers in China
- Participants
- 630 adults8 centers
- Comparison
- Community-based integrated care vs enhanced usual care
- Interventionn = 275
- Enhanced usual caren = 355reference
- Primary endpoint
- Between-group difference in % of patients with ≥50% reduction in depressive symptoms and ≥0.5 percentage-point reduction in HbA1c
- Follow-up
- 12 months
Methodological detailspragmatic, 8 community health centers
- Pragmatic
- 8 community health centers
Primary result
As reported in the abstract
Primary outcome, depressive symptoms component (≥50% reduction)
Risk difference
31.03%
95% CI 21.85–40.21
By group
Interventionvs Enhanced usual care
risk difference 31.03% (95% CI 21.85–40.21)
Further findings
| Outcome | Intervention | Enhanced usual care | Estimate | |
|---|---|---|---|---|
| Primary outcome, HbA1c component (≥0.5 percentage-point reduction) · 12 monthsIntention-to-treat population; missing data multiply imputed | 32.41% | 13.25% | risk difference 19.16% (95% CI 11.35–26.97) | |
| Mental quality of life · 12 months | 46.57 | 39.83 | MD 6.74 (95% CI 3.75–9.74) | |
| Diabetes self-care activities · 12 months | 3.46 | 2.78 | MD 0.69 (95% CI 0.52–0.86) | |
| Medication adherence · 12 months | 6.49 | 5.78 | MD 0.72 (95% CI 0.37–1.07) | |
| Experience of care · 12 months | 3.84 | 2.95 | MD 0.89 (95% CI 0.65–1.12) | |
| −2002040Difference (linear scale) |
Rural subgroup
- Rural participants benefited more from the intervention
Original publication
Effect of Community-Based Integrated Care for Patients With Diabetes and Depression (CIC-PDD) in China: A Pragmatic Cluster-Randomized Trial. Diabetes Care. Published 16 December 2024. doi:10.
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