Effect of gastric distension with concurrent small intestinal saline or glucose infusion on incretin hormone secretion in healthy individuals: A randomized, controlled, crossover study
Authors' conclusion
Gastric distension, either alone or during small intestinal glucose exposure, does not stimulate incretin hormone secretion significantly in healthy humans.
Study context
- Population
- Healthy participants (2 females, 6 males), mean age 69.3 ± 1.2 years, BMI 23.5 ± 0.8 kg/m²each studied on 4 occasions
- Participants
- 8 participants
- Comparison
- Gastric distension (intragastric balloon) vs no distension, during intraduodenal saline or glucose infusion
- Primary endpoint
- Plasma GIP and GLP-1 secretion
Methodological detailsrandomized, controlled
- Randomized
- Controlled
Primary result
As reported in the abstract
Plasma GLP-1 and GIP with vs without gastric distension
- No difference in plasma GLP-1 or GIP with or without gastric distension, during saline or glucose infusion
- Saline + distension vs Saline: P = 1.00
- Glucose + distension vs Glucose: P = 1.00
- Saline + distension vs Saline: P = 1.00
- Glucose + distension vs Glucose: P = 0.99
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Effect of gastric distension with concurrent small intestinal saline or glucose infusion on incretin hormone secretion in healthy individuals: A randomized, controlled, crossover study. Diabetes Obes Metab. Published 17 March 2023. doi:10.
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