Early Statin Use Following Diagnosis of Graves’ Disease Is Associated with a Reduced Risk of Moderate-to-Severe Graves’ Orbitopathy in Middle-Aged Adults: Evidence from a Nationwide Taiwanese Cohort
Main finding · Total GO, Group A (<1 year)Result — go to the resultAdjusted hazard ratio 0.66 CI 0.47–0.94Authors' conclusion
Initiating statin treatment within one year after being diagnosed with GD was associated with 34% and 61% reduction in total and moderate-to-severe GO risk, respectively. For patients whose treatment was initiated more than one year after GD was diagnosed, statin use was not related to the risk of total, mild, and moderate-to-severe GO.
Study context
- Population
- Beneficiaries aged >40 years diagnosed with Graves' disease (GD), Taiwan's National Health Insurance Research Database (2009–2019); excluded: incomplete data, follow-up <6 months, prior Graves' orbitopathy (GO), or hyperlipidemia medication before GD diagnosismatched cohort
- Participants
- 47,424 beneficiaries
- Exposure
- Statin users vs nonusers, by interval of statin initiation after GD diagnosis
- Statin users (A, <1 year)n = 4,649
- Nonusers (A, <1 year)n = 18,584reference
- Statin users (B, 1-2 years)n = 3,060
- Nonusers (B, 1-2 years)n = 12,349reference
- Statin users (C, 2-3 years)n = 1,752
- Nonusers (C, 2-3 years)n = 7,030reference
- Outcome
- Risk of GO (total, mild, moderate-to-severe by treatment received)
Methodological detailsnationwide, 1:4 matching on age, sex and duration between GD diagnosis and index day
- Nationwide
- 1:4 matching on age, sex and duration between GD diagnosis and index day
Main finding
Total GO, Group A (<1 year)
Adjusted hazard ratio
0.66
CI 0.47–0.94
P = 0.023
A statin usersvs A nonusers
adjusted HR 0.66 (CI 0.47–0.94); P = 0.023
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted HR (CI) | P value | |
|---|---|---|---|
| Moderate-to-severe GO, Group AA statin usersvs A nonusers | 0.39 (0.19–0.80) | P = 0.010 | |
| Mild GO, Group AA statin usersvs A nonusers | 0.84 (0.56–1.25) | P = 0.385 | |
| 0.20.5125Adjusted hazard ratio (log scale) |
GO risk by statin type or intensity
- Not statistically different among users of various types or intensities of statins in any group
Original publication
Early Statin Use Following Diagnosis of Graves’ Disease Is Associated with a Reduced Risk of Moderate-to-Severe Graves’ Orbitopathy in Middle-Aged Adults: Evidence from a Nationwide Taiwanese Cohort. Thyroid. Published 13 August 2025. doi:10.
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