Clinical Features of Chinese Patients with Thyroid Eye Disease: A Multicenter Retrospective Study
Authors' conclusion
We characterized the clinical features and treatment response of TED in a large Chinese cohort.
Study context
- Population
- Patients with thyroid eye disease (TED) from nine Chinese hospitals, February 2016 to July 2023; mean age 45.96 ± 16.44 years, 63.6% female
- Participants
- 4,157 patients9 hospitals
- Outcome
- Clinical features of TED
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
- Inactive phase
- 55.6% (n = 2310)
- Mean clinical activity score (SD)
- 2.19 ± 1.61
- Mild TED
- 9.3% (n = 385)
- Moderate-to-severe TED
- 82.5% (n = 3428)
- Sight-threatening TED
- 8.2% (n = 344)
- Mean exophthalmos
- 20.04 ± 5.27 mm
- Diplopia
- 48.8% (n = 2029)
Observational data: associations, not effects.
Further findings
Disease activity by I131 treatment
- Higher disease activity in I131-treated patients
- 47.5%, n = 468, vs. 43.5%, n = 1379, p < 0.05
Severity and diplopia, coastal vs inland region
- Sight-threatening cases, coastal vs inland
- 10.1%, n = 195, vs. 7.2%, n = 147
- Diplopia scores, coastal vs inland
- 1.00 ± 1.10 vs. 0.86 ± 1.09, p < 0.001
Severity by consultation department
- Ophthalmology: mild / moderate-to-severe
- 6.0%, n = 213 / 85.6%, n = 3055
- Endocrinology: mild / moderate-to-severe
- 29.3%, n = 172 / 63.5%, n = 373
Nomogram performance
- AUC for sight-threatening TED
- 0.742 (CI 0.716-0.768)
- AUC for intravenous glucocorticoid (IVGC) therapy responsiveness (subgroup n = 126)
- 0.759 (CI 0.674-0.843)
Original publication
Clinical Features of Chinese Patients with Thyroid Eye Disease: A Multicenter Retrospective Study. Thyroid. Published 11 August 2025. doi:10.
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