Early meal timing attenuates high polygenic risk of obesity
Authors' conclusion
Meal timing is associated with weight-loss maintenance and may influence the association between obesity genetics and BMI. Findings underscore the importance of personalized obesity management.
Study context
- Population
- Adults with overweight or obesity from the Obesity, Nutrigenetics, Timing, and Mediterranean (ONTIME) study; mean age 41.07 (SD 12.68) years, 80.8% female, baseline mean BMI 31.32 (SD 5.53) kg/m²
- Participants
- 1,195 adults
- Exposure
- Later vs earlier meal timing, and interaction with PRS-BMI
- Outcome
- Long-term weight-loss maintenance after dietary obesity treatment
- Follow-up
- At least 3 years
Main finding
As reported in the abstract
Long-term body weight per hour of delay in meal timing
Each hour of delay in meal timing: higher long-term body weight (lower weight-loss maintenance), β [SE]
2.177%
1.067%p = 0.042
Observational data: associations, not effects.
Further findings
- Meal timing × PRS-BMI interaction
- P = 0.008
- High PRS-BMI: BMI increase per hour of delay in meal timing, β [SE]
- 2.208 [0.502] kg/m²; p = 1.0E-5
- Lower genetic risk: no associations evident
Original publication
Early meal timing attenuates high polygenic risk of obesity. Obesity (Silver Spring). Published 20 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →