Early-Life Risks of Central Precocious Puberty
Authors' conclusion
Higher maternal GWG was associated with an increased risk of CPP overall, while GWG became negatively associated with CPP, only in females. Maternal GDM was linked to a higher risk of CPP, particularly in males. The duration of exclusive breastfeeding was inversely correlated with CPP risk, but this effect was not significant when analyzed by gender.
Study context
- Population
- Children under pubertal assessment, Taiwan Puberty Longitudinal Study745 had central precocious puberty (CPP)
- Participants
- 2,241 participants
- Exposure
- Early-life risk factors and CPP
- Outcome
- CPP
Methodological detailslongitudinal
- Longitudinal
Main finding
As reported in the abstract
Higher gestational weight gain (GWG), overall: OR
1.03 (1.01-1.05) (95% CI)
Higher GWG, females: OR
0.97 (0.95-0.99) (95% CI)
Maternal gestational diabetes mellitus (GDM), males: OR
2.66 (1.00-7.25) (95% CI)
Longer exclusive breastfeeding, overall: OR
0.96 (0.93-1.00) (95% CI)
Observational data: associations, not effects.
Original publication
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