Early life poly- and perfluoroalkyl substance levels and adiposity in the first 2 years of life
Authors' conclusion
Higher PFAS levels in early life are associated with accelerated gains in FM% during the first 6 months of life and with lower FFM SDS at the age of 2 years, which have been associated with an unfavorable body composition and metabolic profile later in life. Our findings warrant further research with longer follow-up times.
Study context
- Population
- Healthy term-born infants followed to age 2 years
- Participants
- 372 infants
- Exposure
- Higher vs lower PFAS plasma levels at 3 months
- Outcome
- Associations of PFAS levels at 3 months with adiposity
Methodological detailslongitudinal, PFAS plasma levels (5 individual PFASs) measured by liquid chromatography-electrospray ionization-tandem mass spectrometry at 3 months; multiple regression analyses
- Longitudinal
- PFAS plasma levels (5 individual PFASs) measured by liquid chromatography-electrospray ionization-tandem mass spectrometry at 3 months; multiple regression analyses
Main finding
As reported in the abstract
- Higher perfluorooctanoic acid and total PFAS levels associated with accelerated gain in FM% (>0.67 SD score (SDS)) during first 6 months
- Higher PFAS levels associated with lower fat-free mass SDS at 2 years
- No association of PFAS levels with total FM% SDS at 2 years
Observational data: associations, not effects.
Further findings
PFAS levels and exclusive breastfeeding on fat-free mass SDS at 2 years
- Opposite effects of PFAS levels (negative) and exclusive breastfeeding (positive) at 3 months on fat-free mass (FFM) SDS at 2 years
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Early life poly- and perfluoroalkyl substance levels and adiposity in the first 2 years of life. Eur J Endocrinol. Published 30 March 2024. doi:10.
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