Dosing of antidepressants in relation to body weight in children and adolescents with overweight
Authors' conclusion
We conclude that the doses of fluoxetine and sertraline were essentially similar in individuals with overweight or obesity, but the weight-normalized doses were clearly lower.
Study context
- Population
- Children and adolescents with a prescription of fluoxetine or sertraline and a weight measurement; BMI Epidemiology Study (BEST) Gothenburg cohort and National Prescribed Drug Registerfluoxetine n = 347
- Exposure
- Overweight or obesity vs normal weight
- Outcome
- Antidepressant doses in relation to body weight
Methodological detailsregister-based
- Register-based
Main finding
As reported in the abstract
Fluoxetine and sertraline doses and weight-normalized doses
- Fluoxetine: weight-normalized dose lower with overweight or obesity vs normal weight in first and iterated prescriptions
- p < 0.01
- Sertraline: pronounced differences in dose per kg body weight in first and iterated prescriptions
- p < 0.01
Observational data: associations, not effects.
Original publication
Dosing of antidepressants in relation to body weight in children and adolescents with overweight. Int J Obes (Lond). Published 14 November 2024. doi:10.
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