Dose–Response Effect of Glucagon on Glucose, Beta‐Cell Secretion and Metabolism in Healthy Individuals
Authors' conclusion
Infusion of glucagon results in dose-dependent metabolic effects in healthy humans.
Study context
- Population
- Healthy, lean adults
- Participants
- 15 participants
- Outcome
- Dose-dependent metabolic effects of glucagon infusion
Methodological detailsstepwise intravenous infusion, six increasing doses, 180-min stepwise IV infusion of native human glucagon at 0.01, 0.1, 0.5, 1, 10 and 50 ng × kg-1 × min-1
- Stepwise intravenous infusion
- Six increasing doses
- 180-min stepwise IV infusion of native human glucagon at 0.01, 0.1, 0.5, 1, 10 and 50 ng × kg-1 × min-1
Main finding
As reported in the abstract
- Plasma glucose increased dose-dependently, with significant stepwise elevations from intermediate infusion rates, peaking at supraphysiological glucagon levels
- Insulin and C-peptide rose markedly, reflecting β-cell activation
- Plasma cyclic AMP (cAMP) increased only during the highest glucagon infusion rate, despite earlier metabolic responses
- Plasma non-esterified fatty acids, TG and total amino acids declined at higher glucagon doses
- Plasma urea decreased gradually from the second infusion rate onward
Original publication
Dose–Response Effect of Glucagon on Glucose, Beta‐Cell Secretion and Metabolism in Healthy Individuals. Diabetes Obes Metab. Published 21 May 2026. doi:10.
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