Divergent roles of skeletal muscle 11β-HSD1 in age-related and chronic kidney disease-associated sarcopenia
Authors' conclusion
Skeletal muscle 11β-HSD1 activity is not induced by CKD itself, but increases significantly over aging, where it is a predictor of muscle weakness. Its targeted deletion preserves muscle mass in aged mice, supporting its efficacy in preventing sarcopenia in an aging CKD population.
Study context
- Population
- Chronic kidney disease (CKD) patients (eGFR <30 mL/min) and age-matched controls, mean age 71 ± 5 years; quadriceps biopsies
- Participants
- 17 vs 14
- Comparison
- CKD patients vs age-matched controls; Wild-type (WT) vs 11β-HSD1 knockout mice
- CKDn = 17
- Controlsn = 14reference
- Outcome
- Muscle 11β-HSD1 activity
Methodological detailshuman muscle biopsies, primary human myotubes, murine CKD and aging models
- Human muscle biopsies
- Primary human myotubes
- Murine CKD and aging models
Main finding
As reported in the abstract
- Increased with age (r)
- r = 0.559, P = .001
- Predicted lower grip strength
- P = .008
Original publication
Divergent roles of skeletal muscle 11β-HSD1 in age-related and chronic kidney disease-associated sarcopenia. Eur J Endocrinol. Published 30 April 2026. doi:10.
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