Discordance Between Glucose Management Indicator and Glycated Hemoglobin in People Without Diabetes
Authors' conclusion
GMI does not accurately estimate HbA1c in healthy people without diabetes.
Study context
- Population
- Children and nonpregnant adults (age ≥6 years) without diabetes (laboratory HbA1c <5.7%, negative islet antibodies); mean age 31.2 ± 21.0 years, 66.0% female, HbA1c 5.1% ± 0.3%153 analysed
- Participants
- 201 children
- Exposure
- Glucose management indicator (GMI) vs laboratory HbA1c
- Outcome
- Discordance between GMI (from mean sensor glucose, blinded Dexcom G6 up to 10 days) and HbA1c
Methodological detailsmulticentre, blinded continuous glucose monitor (CGM)
- Multicentre
- Blinded CGM
Main finding
As reported in the abstract
Discordance between GMI and HbA1c
Mean GMI higher than laboratory HbA1c
0.59%
Discordance between GMI and HbA1c ≥0.4%, people without diabetes
71%
Discordance between GMI and HbA1c ≥0.4%, original GMI development cohort
39%
Observational data: associations, not effects.
Original publication
Discordance Between Glucose Management Indicator and Glycated Hemoglobin in People Without Diabetes. Diabetes Technol Ther. Published 15 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →