Different FT3/TSH correlation in acquired and congenital hypothyroid patients reveals a different hypothalamic set‐point
Authors' conclusion
Adult CH patients require a higher daily l-T4 dose than adult TP. However, the different correlation of TSH and FT3 values between CH and TP patients suggests an adaptive and different hypothalamic-pituitary-thyroid axis regulation that may depend on the early timing of the onset of hypothyroidism in CH.
Study context
- Population
- Adult congenital hypothyroid (CH) patients (27 males, 71 females), median age 24 years (range 18–58), with thyroidectomized patients (TP) and EU controls followed at a Thyroid Clinic
- Participants
- 98 / 461 / 1,852
- Exposure
- CH patients on levo-thyroxine (l-T4) vs TP on l-T4 vs euthyroid subjects
- CHn = 98
- TPn = 461
- EUn = 1,852reference
- Outcome
- Daily weight-based l-T4 dose
Methodological detailsconsecutive patients, single clinic
- Consecutive patients
- Single clinic
Main finding
As reported in the abstract
P = 0.03
Observational data: associations, not effects.
Further findings
| Outcome | CH | TP | EU |
|---|---|---|---|
| FT3/FT4 ratio | 0.28 | 0.24 | 0.32 |
FT3/FT4 ratio
- Significantly higher in EU, intermediate in CH, lower in TP
FT4–TSH and FT3–TSH correlation (linear regression)
- Inverse correlation between FT4 and TSH in all groups
- Inverse correlation between FT3 and TSH in TP, but not in EU and CH
Original publication
Different FT3/TSH correlation in acquired and congenital hypothyroid patients reveals a different hypothalamic set‐point. Clin Endocrinol (Oxf). Published 22 April 2022. doi:10.
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