Differences in Clinical Presentation Between Pheochromocytomas and Paragangliomas
Authors' conclusion
Pheochromocytomas and paragangliomas exhibit some notable differences in symptoms and hormone profiles but generally share many features. These distinctions are, however, insufficient for clinicians to differentiate the two tumours based solely on clinical presentation or biochemical data.
Study context
- Population
- Patients with PPGLs treated at a major tertiary centre, 2005–2024196 with symptom data
- Participants
- 201 patients
- Exposure
- Pheochromocytoma vs paraganglioma
- Outcome
- Differences in clinical presentation between pheochromocytomas and paragangliomas
Methodological detailssingle tertiary centre
- Single tertiary centre
Main finding
As reported in the abstract
Clinical presentation
Paragangliomas producing increased epinephrine
25.0%
Classic triad (palpitations, sweating, headaches), all patients; similar between groups
12%
Hypertension, all patients; similar between groups
82%
Observational data: associations, not effects.
Original publication
Differences in Clinical Presentation Between Pheochromocytomas and Paragangliomas. Clin Endocrinol (Oxf). Published 10 July 2025. doi:10.
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