Differences in α-Blockade Practices Between Endocrine and Surgical Specialties for Pheochromocytoma and Paraganglioma Resection: A Single-Center Retrospective Study
Authors' conclusion
Despite differences in α-blockade strategies between the groups, perioperative hemodynamic outcomes were comparable, supporting flexibility in management. Tumor burden and patient age were associated with perioperative hemodynamic variability.
Study context
- Population
- Patients with PPGL undergoing laparoscopic or robot-assisted resection, 2006–2023, single academic center
- Participants
- 78 patients
- Exposure
- Preoperative α-blockade by endocrine vs surgical specialties
- Endocrinen = 28
- Surgicaln = 50reference
- Outcome
- Perioperative outcomes
Methodological detailslongitudinal, single-centre
- Longitudinal
- Single-centre
Main finding
As reported in the abstract
Perioperative hemodynamic outcomes
- Perioperative hemodynamic outcomes remained comparable between groups
Observational data: associations, not effects.
Further findings
Duration of α-blockade
Dose of selective α-blockers
Dose of nonselective α-blockers
Daily α-blocker administration frequency
- Higher frequency of daily α-blocker administration in Endocrine vs Surgical
Predictors of hypotension (overall cohort)
- Larger tumor size and higher metanephrine concentrations associated with both systolic and diastolic hypotension
- P < 0.05 for both
Predictors of prolonged systolic BP >160 mmHg (overall cohort)
- Elevated metanephrine levels and older age correlated with prolonged duration of systolic BP >160 mmHg
- P < 0.05
Original publication
Differences in α-Blockade Practices Between Endocrine and Surgical Specialties for Pheochromocytoma and Paraganglioma Resection: A Single-Center Retrospective Study. Endocr Pract. Published 12 September 2025. doi:10.
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