Differences and analogies in thyroid cancer discovered incidentally or by thyroid-related screening: a multicenter study
Authors' conclusion
biological features of TC are similar in the TD and ID groups, but patients in the two groups display significant differences regarding their clinical features.
Study context
- Population
- Consecutive patients with thyroid cancer, three hospital-based centers (Pavia, Latina, Messina), Italy
- Participants
- 327 patients
- Exposure
- Incidental (ID) vs thyroid-related (TD) pre-surgery reasons leading to Thyroid-Cancer (TC) diagnosis
- IDn = 65
- TDn = 262reference
- Outcome
- Prevalence of TD vs ID pre-surgery reasons leading to TC diagnosis
Methodological detailsmulticentre, three high-volume hospital-based centers, Italy
- Multicentre
- Three high-volume hospital-based centers, Italy
Main finding
As reported in the abstract
Pre-surgery reason leading to TC diagnosis
Observational data: associations, not effects.
Further findings
Clinical characteristics and comorbidities
- ID patients more frequently males, significantly older and with higher BMI than TD
- ID had a higher rate of non-thyroidal cancers and cardiovascular/metabolic comorbidities
TC features: histotype, size, extra-thyroidal extension, lymph-node metastases, AJCC staging, ATA risk
- No significant differences between ID and TD
Original publication
Differences and analogies in thyroid cancer discovered incidentally or by thyroid-related screening: a multicenter study. Eur Thyroid J. Published 22 January 2025. doi:10.
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