Difference on Glucose Profile From Continuous Glucose Monitoring in People With Prediabetes vs. Normoglycemic Individuals: A Matched-Pair Analysis
An erratum to this article was published (J Diabetes Sci Technol, Mar 2026 ↗)
Authors' conclusion
Individuals with prediabetes have different glucose profiles compared to normoglycemic individuals. CGM might be helpful in individuals with borderline glucose values for a more accurate reclassification.
Study context
- Population
- Individuals with prediabetes and matched normoglycemic individuals; median age 51 years, median BMI 26.4 kg/m²
- Participants
- 36 individuals18 matched pairs
- Comparison
- Prediabetes vs normoglycemic individuals
- Outcome
- Percentages of CGM glucose readings time below range (TBR) (<54 or <70 mg/dL), time in range (TIR) (70 to 180 mg/dL) and time above range (TAR) (>180 or >250 mg/dL)
Methodological detailsmatched for age, sex and BMI, professional continuous glucose monitoring (CGM) for 1 week, oral glucose tolerance test (OGTT) on second day
- Matched for age, sex and BMI
- Professional CGM for 1 week
- OGTT on second day
Main finding
As reported in the abstract
24-hour TIR
P = 0.013
Further findings
TAR >180 mg/dL · primary outcome
P = 0.0062
24-hour mean interstitial glucose
P = 0.0038
MAGE · favoring normoglycemic
P = 0.0043
Median
| Outcome | Prediabetes | Normoglycemic | P value |
|---|---|---|---|
| CVFavoring normoglycemic | 15.2% | 11.9% | P = 0.0156 |
- Total AUC after OGTT · 2 hours post OGTT · lower with Normoglycemic
- P = 0.0347
- Incremental AUC after OGTT · 2 hours post OGTT · lower with Normoglycemic
- P = 0.0429
Original publication
Difference on Glucose Profile From Continuous Glucose Monitoring in People With Prediabetes vs. Normoglycemic Individuals: A Matched-Pair Analysis. J Diabetes Sci Technol. Published 13 September 2022. doi:10.
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