Diagnostic Performance of ACR Thyroid Imaging Reporting and Data System (TI-RADS) and Sonographic Predictors of Malignancy in Pediatric Thyroid Nodules
Authors' conclusion
In this tertiary-care, surgically managed pediatric cohort, American College of Radiology TI-RADS showed reasonable discrimination but limited rule-out performance in TR1-TR3. Srivatsa PED TI-RADS improved sensitivity at the cost of lower specificity.
Study context
- Population
- Pediatric patients surgically treated for a thyroid nodule, tertiary care60 (60.6%) malignant
- Participants
- 99 participants
- Exposure
- ACR TI-RADS vs Srivatsa PED TI-RADS
- Outcome
- Diagnostic performance for malignancy
Methodological detailsdiagnostic performance analysis, external validation of Srivatsa PED TI-RADS biopsy thresholds
- Diagnostic performance analysis
- External validation of Srivatsa PED TI-RADS biopsy thresholds
Main finding
As reported in the abstract
| Group | Biopsy eligibility (vs 53.6%) | Sensitivity (vs 69.0%) | Specificity (vs 69.2%) |
|---|---|---|---|
| Srivatsa PED TI-RADS | 62.9% | 77.6% | 59.0% |
Srivatsa PED TI-RADS
Biopsy eligibility (vs 53.6%)62.9%
Sensitivity (vs 69.0%)77.6%
Specificity (vs 69.2%)59.0%
Observational data: associations, not effects.
Further findings
| Outcome | Srivatsa PED TI-RADS |
|---|---|
| Biopsy thresholds: Srivatsa PED TI-RADS vs ACR TI-RADS | |
| Biopsy eligibility | 62.9% |
| Sensitivity | 77.6% |
| Specificity | 59.0% |
- Biopsy thresholds: Srivatsa PED TI-RADS vs ACR TI-RADS: ACR TI-RADS biopsy eligibility 53.6% · sensitivity 69.0% · specificity 69.2%
Independent sonographic predictors of malignancy
- Irregular margins (OR 13.3)
- P = 0.03
- Microcalcifications (OR 5.9)
- P < 0.001
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Diagnostic Performance of ACR TI-RADS and Sonographic Predictors of Malignancy in Pediatric Thyroid Nodules. Endocr Pract. Published 11 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →