Diagnosis and management of urinary bladder paragangliomas: A Sino‐American‐European retrospective observational study
Authors' conclusion
Most patients with UBPGL are diagnosed after surgery. Young age, hypertension, micturition spells and sweating are clues in assisting to initiate early biochemical testing and thus may establish a timely presurgical diagnosis.
Study context
- Population
- Patients with paragangliomas of the urinary bladder (UBPGLs); 11 centres in China, 6 in Europe and 1 in the United States73 China, 51 Europe/US
- Exposure
- Diagnosed before vs after surgery
- Outcome
- Factors associated with missing the diagnosis of UBPGLs before surgery (initiation of presurgical biochemical testing)
Methodological detailsmulticentre, international (China, Europe, United States)
- Multicentre
- International (China, Europe, United States)
Main finding
As reported in the abstract
Diagnosed before surgery
- Age <35 years
- OR 6.47; P = 0.013
- Micturition spells
- OR 6.79; P = 0.007
- Hypertension
- OR 3.98; P = 0.011
- Sweating
- OR 41.72; P = 0.013
- Diagnosed before surgery
- 47.6%
Observational data: associations, not effects.
Further findings
Age
P < 0.001
Tumour size
P < 0.001
SDHB pathogenic variant
P < 0.001
Micturition spells
P = 0.003
Hypertension
P = 0.041
Catecholamine-related symptoms
P = 0.012
Original publication
Diagnosis and management of urinary bladder paragangliomas: A Sino‐American‐European retrospective observational study. Clin Endocrinol (Oxf). Published 12 April 2024. doi:10.
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