Diabetic Ketoacidosis and Long-term Insulin Requirements in Youths with Newly Diagnosed Type 2 Diabetes During the SARS-CoV-2 Pandemic
Authors' conclusion
The incidence of DKA at the onset of type 2 diabetes was higher during the SARS-CoV-2 pandemic than in the prepandemic period. SARS-CoV-2 infection was not associated with DKA severity or insulin discontinuation within the first year of diagnosis in youth with new-onset type 2 diabetes and DKA.
Study context
- Population
- Youths with obesity aged 10 to 21 years with new-onset T2D admitted with DKA, January 2018 to January 2022; 85.8% Black or Hispanic
- Participants
- 38 / 10 / 28 / 110
- Exposure
- DKA precipitated by infection vs no infection
- Any infectionn = 38
- SARS-CoV-2n = 10
- Other infectionn = 28
- No infectionn = 110reference
- Outcome
- Insulin discontinuation
- Follow-up
- 12-month follow-up
Methodological detailssingle-center
- Single-center
Main finding
As reported in the abstract
Discontinued all insulin within first year
46 patients
Time to insulin discontinuation
9 months
IQR, 4–14
Observational data: associations, not effects.
Further findings
DKA severity
- No differences in DKA severity among groups
Incidence of DKA, pandemic (March 2020-January 2022) vs prepandemic (January 2018-February 2020)
- Higher during pandemic; admissions pandemic
- 117
- Admissions prepandemic
- 31
Insulin restart after discontinuation
- Restarted insulin
- 16 subjects
- Time to restart after discontinuation
- 10 months (IQR, 6.5-11.0)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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