Diabetic Foot Ulcers Are Clinical Marker of Disease Burden in People With Diabetes and Heart Failure
Authors' conclusion
In people with diabetes and heart failure, diabetic foot ulcer occurrence was independently associated with increased mortality in the time-varying analysis.
Study context
- Population
- Adults with DM and HF treated at a large single centre in the Netherlands (2002–2021)
- Participants
- 4,937 adults
- Exposure
- DFU vs no DFU
- DFUn = 908
- Outcome
- All-cause mortality and hospitalisation for decompensated HF
- Follow-up
- 3 years
Methodological detailssingle-centre, multivariable Cox regression, time-varying Cox model
- Single-centre
- Multivariable Cox regression
- Time-varying Cox model
Main finding
As reported in the abstract
All-cause mortality · first 3 years after HF diagnosis
- Mortality differences were modest during the first 3 years after HF diagnosis
- Hospitalisation rates showed similar patterns
Observational data: associations, not effects.
Further findings
Mortality with follow-up from ulcer diagnosis · 1 year
P < 0.001
Mortality at 5 years after HF diagnosis
- Mortality differences modest during first 3 years after HF diagnosis but significant at 5 years (DFU vs no DFU)
- 32.0% vs. 25.1%, p < 0.001
Hospitalisation for decompensated HF
- Hospitalization rates showed similar patterns
Original publication
Diabetic Foot Ulcers Are Clinical Marker of Disease Burden in People With Diabetes and Heart Failure. Diabetes Obes Metab. Published 21 July 2026. doi:10.
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