Diabetes Status and Cardiovascular Complications Risk in Noncardiac Surgery: A Population-Based Cohort Study
Authors' conclusion
In this cohort, a notable proportion of patients with prediabetes or undiagnosed diabetes were found to be undergoing noncardiac surgeries. They were associated with an increased risk of developing postoperative MACE.
Study context
- Population
- Patients undergoing noncardiac surgery, categorized by glycemic status (HbA1c levels)
- Participants
- 13,207 patients
- Exposure
- Prediabetes, undiagnosed diabetes and diagnosed diabetes vs nondiabetes
- Prediabetesn = 3,841
- Undiagnosed diabetesn = 1,521
- Outcome
- MACE
- Follow-up
- 30 days postoperatively
Methodological detailsperioperative cohort
- Perioperative cohort
Main finding
As reported in the abstract
Each group vs nondiabetesHazard ratio (95% CI)
Prediabetes
1.70(1.15–2.52)
Undiagnosed diabetes
2.36(1.15–3.68)
Diagnosed diabetes
2.33(1.54–3.53)
Observational data: associations, not effects.
Secondary outcomes
Major adverse cardiovascular events (MACE) at 90 days · 90 days postoperatively
- Similar findings observed for 90-day postoperative MACE
Interaction between sex and glycemic regulation status (subgroup analysis)
- Significant interaction between sex and states of glycemic regulation
- P for interaction < 0.005
Original publication
Diabetes Status and Cardiovascular Complications Risk in Noncardiac Surgery: A Population-Based Cohort Study. Endocr Pract. Published 25 February 2025. doi:10.
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