Diabetes Risk Factors and Bone Microarchitecture as Assessed by High-Resolution Peripheral Quantitative Computed Tomography in Adults With Long-standing Type 1 Diabetes
Authors' conclusion
Type 1 diabetes is associated with lower BMD, larger bone area, and poorer trabecular microarchitecture. Among participants with type 1 diabetes, suboptimal glycemic control, AGE accumulation, and microvascular complications are associated with deficits in bone microarchitecture and lower BMD.
Study context
- Population
- Adults with long-standing T1D (>30 years of follow-up) from DCCT/EDIC and controls without diabetes; High-resolution peripheral quantitative computed tomography (HR-pQCT) of distal radius and distal and diaphyseal tibia
- Participants
- 183 vs 94
- Exposure
- T1D vs controls without diabetes
- EDICn = 183
- Controln = 94reference
- Outcome
- Bone geometry and microarchitecture (HR-pQCT)
Methodological detailsembedded in a long-term observational study
- Embedded in a long-term observational study
Main finding
As reported in the abstract
EDIC vs ControlEstimate (95% CI)P value
EDIC
difference in total BMD, distal radius −7.9 %(−15.2% to −0.6%)
P = 0.030EDIC
difference in total BMD, distal tibia −11.3 %(−18.5% to −4.2%)
P = 0.001Larger with EDIC
difference in total area, distal radius 4.7 %(0.5%–8.8%)
P = 0.030Larger with EDIC
difference in total area, distal tibia 5.9 %(2.1%–9.8%)
P = 0.003Larger with EDIC
difference in total area, diaphyseal tibia 3.4 %(0.8%–6.1%)
P = 0.011Observational data: associations, not effects.
Further findings
Diabetes risk factors and bone within EDIC
- Higher HbA1c, AGE levels and macroalbuminuria associated with lower total bone mineral density (BMD)
- Macroalbuminuria associated with larger total area and lower cortical thickness at distal radius
- Higher HbA1c and AGE levels, lower GFR, peripheral neuropathy and retinopathy associated with deficits in trabecular microarchitecture
Original publication
Diabetes Risk Factors and Bone Microarchitecture as Assessed by High-Resolution Peripheral Quantitative Computed Tomography in Adults With Long-standing Type 1 Diabetes. Diabetes Care. Published 29 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →