Diabetes-related genetics and outcomes after total pancreatectomy with islet autotransplantation
Authors' conclusion
T2D genetic risk is associated with diabetes prior to TPIAT, and beta cell and lipodystrophy PGS are associated with post-TPIAT diabetes outcomes.
Study context
- Population
- Patients with chronic pancreatitis undergoing total pancreatectomy with islet autotransplantation (TPIAT); 29±17 years old, 61% female, 84% non-Hispanic White, 13% with diabetes prior to transplantgenotyped
- Participants
- 318 patients
- Exposure
- T1D- and T2D-GRS and partitioned metabolic polygenic scores (PGS) vs diabetes outcomes
- Outcome
- Associations of T1D- and T2D-GRS and metabolic PGS with diabetes before TPIAT and metabolic outcomes after transplant
- Follow-up
- One year after TPIAT
Methodological detailsmulticenter
- Multicenter
Main finding
As reported in the abstract
T2D-GRS by pre-TPIAT diabetes status
Pre-TPIAT diabetes
−0.6
± 0.3
No pre-TPIAT diabetes
−0.8
± 0.2
P = 0.003
- T2D-GRS associated with higher pre-transplant HbA1c (β per 1-SD)
- β=0.19 % (95% CI 0.04, 0.33), p = 0.011
- Beta-cell PGS associated with higher insulin dose 1-year post-transplant (β per 1-SD; adjusted for genotype-derived ancestry and islet equivalents/kg)
- β=0.05 units/kg/day (95% CI 0.01, 0.09), p=0.016
- Beta-cell PGS associated with higher insulin dose adjusted A1c (IDAA1c) 1-year post-transplant (adjusted)
- β=0.34 (95% CI 0.03, 0.67), p=0.029
- Lipodystrophy PGS associated with higher IDAA1c at 1 year
- β=0.38 (95% CI 0.06, 0.69), p=0.019
- Lipodystrophy PGS associated with lower fasting C-peptide at 1 year
- β=−0.09 (95% CI −0.18, 0), p=0.041
Observational data: associations, not effects.
Original publication
Diabetes-related genetics and outcomes after total pancreatectomy with islet autotransplantation. J Clin Endocrinol Metab. Published 11 September 2026. doi:10.
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