Diabetes mellitus with mild or moderate kidney dysfunction is associated with poor prognosis in patients with coronary artery disease: A large-scale cohort study
Authors' conclusion
DM with mild or moderate kidney dysfunction is associated with poor prognosis in CAD patients. Categorical classification of patients with DM and kidney dysfunction could provide prognostic information for risk stratification of CAD patients.
Study context
- Population
- Patients with coronary artery disease (CAD) hospitalized for percutaneous coronary intervention (PCI) at Fuwai hospital, January–December 2013
- Participants
- 9,293 patients
- Exposure
- Combined DM status and kidney function stage vs stage I/non-DM
- Outcome
- MACCEs: composite of all-cause mortality, MI and stroke
- Follow-up
- Median 2.4 years
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
MACCE risk
Each group vs stage I/non-DMAdjusted hazard ratio (95% CI)P value
Stage II/DM
1.53(1.09–2.15)
P = 0.014Stage III/DM
3.00(1.74–5.18)
P < 0.002- Major adverse cardiovascular and cerebrovascular events (MACCEs) occurred (all patients)
- 326 (3.5%)
Observational data: associations, not effects.
Further findings
Estimated glomerular filtration rate (eGFR) and MACCE risk
- J-shaped associations of eGFR with MACCE risk regardless of glycemic metabolism status, after adjustment for confounders
MACCE risk with moderate kidney dysfunction in diabetic patients with uncontrolled glycemia
- Moderate kidney dysfunction conferred increased MACCE risk, aHR
- 2.93 (95% CI 1.48-5.78; P = 0.002)
Original publication
Diabetes mellitus with mild or moderate kidney dysfunction is associated with poor prognosis in patients with coronary artery disease: A large-scale cohort study. Diabetes Res Clin Pract. Published 7 May 2023. doi:10.
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