Diabetes Mellitus and Early Antiplatelet Treatment for Minor Stroke Following Intravenous Thrombolysis: Prespecified Secondary Analysis of the EAST Trial
Primary result · Excellent functional outcome (mRS 0-1) by DM statusResult — go to the resultAdjusted odds ratio 2.76 95% CI 1.22–6.22Authors' conclusion
For Chinese patients with minor stroke receiving intravenous thrombolysis, early DAPT was potentially associated with a higher likelihood of excellent functional outcome at 90 days in those with a pre-existing history of DM.
Study context
- Population
- Chinese patients with minor stroke receiving intravenous thrombolysis, stratified by diabetes mellitus (DM) status (history of DM, newly diagnosed DM, non-DM)analysed
- Participants
- 995 patients
- Comparison
- Early dual antiplatelet therapy (DAPT) vs placebo after intravenous thrombolysis, by DM status
- Primary endpoint
- Excellent functional outcome (modified Rankin Scale score 0-1)
- Follow-up
- 90 days
Methodological detailsprespecified, subgroup analysis by DM status, modified intention-to-treat population
- Prespecified
- Subgroup analysis by DM status
- Modified intention-to-treat population
Primary result
As reported in the abstract
Excellent functional outcome (mRS 0-1) by DM status
Adjusted odds ratio
2.76
95% CI 1.22–6.22
P = 0.02
Early DAPTvs Placebo
adjusted OR 2.76 (95% CI 1.22–6.22); P = 0.02
- History of DM: Early DAPT vs placebo
- 91.2% vs. 81.7%
- Newly diagnosed DM: Early DAPT vs placebo
- 81.8% vs. 83.3%
- Non-DM: Early DAPT vs placebo
- 89.6% vs. 92.5%
- Interaction across subgroups not significant
- P for interaction = 0.09
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Diabetes Mellitus and Early Antiplatelet Treatment for Minor Stroke Following Intravenous Thrombolysis: Prespecified Secondary Analysis of the EAST Trial. Diabetes Obes Metab. Published 7 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →