Diabetes and chronic kidney disease in Chinese adults: a population-based cohort study
Main finding · CKDResult — go to the resultHazard ratio 4.52 95% CI 4.23–4.83Authors' conclusion
Among Chinese adults, diabetes was positively associated with CKD, DKD, and glomerulonephritis. Screen-detected and uncontrolled DM had a high risk of CKD, and pre-diabetes was associated with a greater risk of DKD, highlighting the significance of lifelong glycemic management.
Study context
- Population
- Chinese adults, China Kadoorie Biobank
- Participants
- 472,545 adults
- Exposure
- Diabetes status and random plasma glucose (RPG) vs no diabetes
- Outcome
- Incident CKD (including CKD subtypes)
- Follow-up
- 11.8 years of mean
Methodological detailsprospective
- Prospective
Main finding
CKD · 11.8 years mean follow-up
Hazard ratio
4.52
95% CI 4.23–4.83
Screened plus previously diagnosed diabetesvs No diabetes
HR 4.52 (95% CI 4.23–4.83)
As reported in the abstract
- Adults who developed chronic kidney disease (CKD)
- 5417
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| DKD | 33.85 (29.56–38.76) | |
| Glomerulonephritis | 1.66 (1.40–1.97) | |
| 0.050.21520Hazard ratio (log scale) |
Uncontrolled vs controlled previously diagnosed diabetes
- Uncontrolled diabetes had higher risks of CKD, diabetic kidney disease (DKD) and glomerulonephritis than controlled RPG
DKD by pre-diabetes and RPG
- DKD risk rose with pre-diabetes and increased with elevated RPG, even without diabetes
Original publication
Diabetes and chronic kidney disease in Chinese adults: a population-based cohort study. BMJ Open Diabetes Res Care. Published 24 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →