Developmental Trajectory of Body Weight in Youths at Risk for Major Mood Disorders
Main finding · zBMI, overallResult — go to the resultβ 0.12 95% CI 0.01–0.24Authors' conclusion
In this cohort study, females with a family history of mood disorders were prone to weight gain starting around puberty and predating mood disorder onset. Early interventions aiming to prevent adverse mental and physical outcomes in this vulnerable group need to start in childhood.
Study context
- Population
- Unaffected female and male offspring aged 3 to 20 years of parents with or without a mood disorder; mean age 11.5 years, 51.5% female; follow-up mean 5 years, 2014–2022
- Participants
- 394 participants
- Exposure
- Youth at familial risk for mood disorders vs controls
- Outcome
- Age- and sex-adjusted BMI z scores (zBMIs) from measured weight and height at annual assessments
Methodological detailscommunity-based, single-centre, acceleration cohort, yearly follow-ups
- Community-based
- Single-centre
- Acceleration cohort
- Yearly follow-ups
Main finding
zBMI, overall
β
0.12
95% CI 0.01–0.24
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | β (95% CI) |
|---|---|
| zBMI in females, age 12 years and olderHigher in females at familial risk | 0.57 (0.31–0.82) |
zBMI in females, age 12 years and older
- Rapid peripubertal increase in body weight in females at familial risk, independent of socioeconomic status, prematurity, or birth weight
zBMI in males
- Males did not differ from controls at any age
Original publication
Developmental Trajectory of Body Weight in Youths at Risk for Major Mood Disorders. JAMA Netw Open. Published 2 October 2023. doi:10.
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