Determination of Time in Range Associated With HbA1c ≤7% in a Prospective Cohort of Patients With Type 1 Diabetes Using Continuous Glucose Monitoring for Three Months
Authors' conclusion
Our data suggest that the %TIR adequately identifies patients with HbA1c ≤7%. A target of TIR ≥75%, rather than the currently recommended TIR ≥70%, may be a more suitable value for optimal glycemic control.
Study context
- Population
- Patients with T1D treated with hybrid closed loop (HCL), followed for three months; 58.1% women, 47% overweight or obese, 33% with high glycemic variability
- Participants
- 118 patients
- Outcome
- Ability of %TIR to distinguish patients with HbA1c ≤7% (ROC curve analysis)
- Follow-up
- Three months
Methodological detailsprospective, cohort-based
- Prospective
- Cohort-based
Performance
As reported in the abstract
Discrimination of HbA1c ≤7% by %TIR
| Test or model | AUC | Best cutoff | Sensitivity | Specificity |
|---|---|---|---|---|
| %TIR | 0.7485 (95% CI 0.6608-0.8363) | %TIR ≥75.5 | 70% | 67% |
%TIR
AUC0.7485 (95% CI 0.6608-0.8363)
Best cutoff%TIR ≥75.5
Sensitivity70%
Specificity67%
- Moderate negative correlation between %TIR and HbA1c (R = −.54)
- P < 0.001
Further findings
Subgroup with CV ≥36%
- Findings were similar among those with CV ≥36%
Original publication
Determination of Time in Range Associated With HbA1c ≤7% in a Prospective Cohort of Patients With Type 1 Diabetes Using Continuous Glucose Monitoring for Three Months. J Diabetes Sci Technol. Published 5 July 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →