Depression and anxiety in patients with endogenous Cushing syndrome: a nationwide matched-cohort study using affective drug dispensations
Main finding · New-onset ADDResult — go to the resultHazard ratio 2.23 95% CI 1.89–2.62Authors' conclusion
Endogenous CS is associated with a persistently increased risk of treated affective disorders at diagnosis and throughout long-term follow-up
Study context
- Population
- Patients with endogenous cushing syndrome (CS) (2000–2024), Clalit Health Services database; mean age 47.79 ± 17.01 years, 64.44% women; mood and anxiety disorders identified through affective drug dispensations (ADD)matched cohort
- Participants
- 540 vs 2,517
- Exposure
- Endogenous CS vs matched controls
- CSn = 540
- Controlsn = 2,517reference
- Outcome
- Treated mood and anxiety disorders (affective drug dispensations, ADD)
- Follow-up
- Median 13.20 years (IQR 8.41-18.42)
Methodological detailsnationwide, matched 1:5 by age, sex, socioeconomic status and BMI, landmark analysis
- Nationwide
- Matched 1:5 by age, sex, socioeconomic status and BMI
- Landmark analysis
Main finding
New-onset ADD · entire follow-up
Hazard ratio
2.23
95% CI 1.89–2.62
CSvs Controls
HR 2.23 (95% CI 1.89–2.62)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | CS | Controls | Estimate | |
|---|---|---|---|---|
| ADD at baseline, women | 12.93% | 6.93% | OR 1.99 (95% CI 1.38–2.87) | |
| Drug discontinuation · entire follow-up | HR 0.72 (95% CI 0.50–1.04) | |||
| 0.20.5125Ratio (log scale) |
New-onset ADD, Cushing disease
| HR (95% CI) | ||
|---|---|---|
| Cushing disease | 2.44 (1.90–3.13) | |
| 0.20.5125Hazard ratio (log scale) |
New-onset ADD, adrenal CS
| HR (95% CI) | ||
|---|---|---|
| Adrenal CS | 2.17 (1.64–2.88) | |
| 0.20.5125Hazard ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Depression and anxiety in patients with endogenous Cushing syndrome: a nationwide matched-cohort study using affective drug dispensations. Eur J Endocrinol. Published 21 July 2026. doi:10.
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