Decoding Lymph Node Skip Metastasis: Impact on Long-Term Outcomes in Stage T1 Papillary Thyroid Carcinoma
Authors' conclusion
The RFS among stage T1 PTC patients with sN1b stage was comparable to those with N1a and N1b stages. LNPR risk stratification emerged as a significant prognostic factor.
Study context
- Population
- Patients with unilateral T1-stage papillary thyroid carcinoma (PTC) who underwent lobectomy, 2007–2015after propensity score matching (PSM)
- Participants
- 372 patients
- Exposure
- Skipping N1b (sN1b) vs N1a vs N1b
- Outcome
- Recurrence-free survival (RFS)
- Follow-up
- Average 82 months
Methodological detailspropensity score matching
- Propensity score matching
Main finding
As reported in the abstract
Recurrence / RFS
sN1b vs N1a: P = 0.65 · sN1b vs N1b: P = 0.66
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Number of positive lymph nodessN1b vs N1a · comparable | P = 0.77 |
| Number of positive lymph nodessN1b vs N1b · significantly lower with sN1b | P < 0.0001 |
Lymph node positivity rate (LNPR) risk stratification in sN1b
- Strong prognostic discrimination
- P = 0.0067
Original publication
Decoding Lymph Node Skip Metastasis: Impact on Long-Term Outcomes in Stage T1 Papillary Thyroid Carcinoma. Eur J Endocrinol. Published 15 March 2025. doi:10.
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