Decision Regret Following the Choice of Surgery or Active Surveillance for Small, Low-Risk Papillary Thyroid Cancer: A Prospective Cohort Study
Authors' conclusion
In this study of patients with small, low-risk PTC, the mean level of decision regret pertaining to the initial disease management choice was relatively low after one year and it did not differ significantly for respondents who chose AS or surgery.
Study context
- Population
- Canadian patients with small (<2 cm) low-risk papillary thyroid cancer (PTC) offered the choice of active surveillance (AS) or surgery; mean age 53 years (SD 15), 77% female95.5% response rate
- Participants
- 191 patients
- Exposure
- AS vs surgery
- ASn = 151
- Surgeryn = 40reference
- Outcome
- Mean decision regret scale total score
- Follow-up
- One year after treatment decision
Methodological detailsobservational
- Observational
Main finding
As reported in the abstract
Decision regret scale total score · one year
AS
22.4
mean · SD 13.9
Surgery
20.9
mean · SD 12.2
AS vs Surgery: P = 0.730 · AS vs Surgery: P = 0.29
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Beta coefficient (CI) | P value |
|---|---|---|
| Decision regret by treatment status: AS crossed over to surgery vs remaining under AS · one yearAdjusted; higher regret with crossover | 10.1 (1.3–18.9) | P = 0.02 |
| Symptoms interfering with lifeAdjusted; greater interference with surgery | P = 0.02 |
- Decision regret by treatment status: AS crossed over to surgery vs remaining under AS: 7.3% (11/151) of AS crossed over to definitive treatment (two for disease progression)
Depression, anxiety, fear of disease progression, overall body image perception
- No significant group differences
- Adjusted analyses
Original publication
Decision Regret Following the Choice of Surgery or Active Surveillance for Small, Low-Risk Papillary Thyroid Cancer: A Prospective Cohort Study. Thyroid. Published 8 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →