Cystatin C: Not Only a Kidney Marker but Also a Potential Early Indicator of Metabolic Alterations in Childhood Obesity
Authors' conclusion
Elevated cystatin C in children with overweight and obesity is independently associated with central adiposity and IR, supporting its potential as an integrated early marker of metabolic and kidney risk.
Study context
- Population
- Children with overweight and obesity
- Participants
- 169 children
- Exposure
- Cystatin C tertiles
- Outcome
- Relationship between cystatin C and measures of adiposity, insulin resistance (IR) and cardiometabolic risk
Methodological detailsretrospective
- Retrospective
Main finding
As reported in the abstract
- Highest cystatin C tertile had higher standard deviation score-body mass index (SDS-BMI), waist circumference (WC), systolic and diastolic BP SDS, and iCARE index
- Highest tertile also had elevated Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), fasting glucose-to-insulin ratio and TG-to-HDL-C ratio
- Glucose excursion did not differ
- Stepwise regression: WC and HOMA-IR independent predictors of cystatin C
Observational data: associations, not effects.
Original publication
Cystatin C: Not Only a Kidney Marker but Also a Potential Early Indicator of Metabolic Alterations in Childhood Obesity. Horm Res Paediatr. Published 11 August 2026. doi:10.
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