Cortical and Trabecular Bone Deficit in Middle‐Aged Men Living with HIV
Authors' conclusion
MLWH had lower hip bone density with cortical and trabecular bone deficit compared to community-dwelling controls.
Study context
- Population
- Consecutive MLWH aged ≥30 years undergoing quantitative CT, Severance Hospital, Seoul, Korea, November 2017–October 2018; mean age 47.2 years, body mass index (BMI) 23.6 kg/m²matched 1:2
- Exposure
- Men living with HIV vs community-based healthy controls
- Outcome
- Hip vBMD and cortical bone mapping parameters
Methodological detailsage- and BMI-matched controls (1:2), consecutive, single-centre
- Age- and BMI-matched controls (1:2)
- Consecutive
- Single-centre
Main finding
As reported in the abstract
Adjusted β, total hip volumetric bone mineral density (vBMD)
−18.8
P < 0.05 for all
MLWH vs Controls
Adjusted β, CMSD
−7.3
P < 0.05 for all
MLWH vs Controls
Adjusted β, ECTD
−18.0
P < 0.05 for all
MLWH vs Controls
Observational data: associations, not effects.
Further findings
Factors at antiretroviral treatment initiation associated with total hip vBMD and CMSD in MLWH
- Lower CD4 T-cell count (/100 cells/mm³ decrement): adjusted β total hip vBMD
- −7.5
- Protease inhibitor (PI)-based vs non-PI regimen: adjusted β total hip vBMD
- −28.3
- Lower CD4 T-cell count: adjusted β CMSD
- −2.6
- PI-based vs non-PI regimen: adjusted β CMSD
- −12.7
- p < 0.05 for all
- Adjusted for age, BMI, smoking, alcohol use, hepatitis C co-infection, tenofovir exposure, CT scanner types
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Cortical and Trabecular Bone Deficit in Middle‐Aged Men Living with HIV. J Bone Miner Res. Published 11 July 2023. doi:10.
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