Cord blood adiponectin and leptin concentrations in monochorionic twins with selective intrauterine growth restriction and their associations with childhood growth trajectories
Authors' conclusion
Cord blood adiponectin concentrations were negatively associated with IUGR but did not predict childhood growth. Cord blood leptin concentrations were inversely associated with weight and height increments in the first 6 months.
Study context
- Population
- Monochorionic twins with selective intrauterine growth restriction (IUGR) and normal monochorionic twins; growth followed from birth to 24 months
- Exposure
- Monochorionic (MC) twins with selective IUGR (sIUGR) vs normal MC twins
- sIUGRn = 22 pairs
- Normaln = 20 pairsreference
- Outcome
- Cord blood adiponectin and leptin concentrations and their associations with childhood growth trajectories
Main finding
As reported in the abstract
birth
Β (adiponectin, association with IUGR)
−1.51
95% CI −2.45 to −0.57P = 0.002
sIUGR
Leptin
2.8 ± 1.6 vs. 6.4 ± 3.0
P < 0.001
lower in sIUGR twins
Observational data: associations, not effects.
Further findings
Adiponectin and height increment · birth to 6 months
- Adiponectin negatively associated with height increment, β
- −0.28 (−0.51, −0.06), p = 0.015 (95% CI)
Leptin and weight · 6 and 24 months
- Leptin vs weight at 6 months, β
- −0.12 (−0.22, −0.02), p = 0.002 (95% CI)
- Leptin vs weight at 24 months, β
- −0.18 (−0.33, −0.03), p = 0.019 (95% CI)
Leptin and weight/height increments · birth to 6 months
- Leptin vs weight increment, β
- −0.17 (−0.29, −0.06), p = 0.020 (95% CI)
- Leptin vs height increment, β
- −0.40 (−0.81, −0.01), p = 0.037 (95% CI)
Original publication
Cord blood adiponectin and leptin concentrations in monochorionic twins with selective intrauterine growth restriction and their associations with childhood growth trajectories. Pediatr Obes. Published 5 April 2023. doi:10.
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