Continuous Glucose Monitoring Provides Durable Glycemic Benefit in Adolescents and Young Adults with Type 1 Diabetes: 12-Month Follow-Up Results
Authors' conclusion
This further evaluation of CGM supports the findings of the preceding RCT that use of CGM improves glycemic control and reduces hypoglycemia in adolescents and young adults with type 1 diabetes. This trial is
Study context
- Population
- Adolescents and young adults aged 14 to <25 years with suboptimally controlled T1Drandomised in preceding randomized clinical trial (RCT)
- Participants
- 153 adolescents
- Comparison
- Continuous Glucose Monitoring (CGM) continued vs CGM initiated after blood glucose monitoring (BGM); within-cohort changes
- CGM-CGMn = 70
- BGM-CGMn = 70
Methodological detailsobservational extension phase, 26-week extension, No participants discontinued CGM use during the extension phase
- Observational extension phase
- 26-week extension
- No participants discontinued CGM use during the extension phase
Primary result
As reported in the abstract
HbA1c · 52 weeks (CGM-CGM); 26 weeks of CGM use (BGM-CGM)
- CGM-CGM: mean hemoglobin A1c (HbA1c) 8.9% ± 0.9% (74 ± 9.8 mmol/mol) at randomization to 8.3% ± 1.3% (67 ± 14.2 mmol/mol) at 52 weeks
- p < 0.001
- BGM-CGM: mean HbA1c 8.9% ± 1.2% (74 ± 13.1 mmol/mol) before CGM to 8.5% ± 1.3% (69 ± 14.2 mmol/mol) after 26 weeks of CGM
- p < 0.001
Further findings
TIR 70-180 mg/dL
- BGM-CGM: mean TIR increased from 34% ± 12% to 38% ± 15%
- P = 0.01
- CGM-CGM: no significant improvement, 38% ± 13% prerandomization to 41% ± 18% at 52 weeks
Median percent time <70 mg/dL
- CGM-CGM: 3.0% before randomization to 1.1% at 52 weeks
- P < 0.001
- BGM-CGM: 3.3% before CGM initiation to 1.2% after 26 weeks of CGM
- P < 0.001
Original publication
Continuous Glucose Monitoring Provides Durable Glycemic Benefit in Adolescents and Young Adults with Type 1 Diabetes: 12-Month Follow-Up Results. Pediatr Diabetes. Published 26 October 2023. doi:10.
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