Compromised Adult Height in Females with Non-Classical Congenital Adrenal Hyperplasia Diagnosed in Childhood
Authors' conclusion
AHt of females diagnosed with NCCAH in childhood was lower than their THt. Glucocorticoid treatment duration and dose, pubertal status at diagnosis, and having CPP or EP were not correlated with AHt.
Study context
- Population
- Females diagnosed with non-classical CAH (non-classical congenital adrenal hyperplasia (NCCAH)) at age <18 years who reached adult height
- Participants
- 109 females
- Exposure
- Adult height (AHt) vs target height (THt) and Ht-SDS at diagnosis
- Outcome
- AHt compared to target height (THt)
Methodological detailsMean age at diagnosis 9.7 ± 4.4 years; mean follow-up 10.9 ± 6.3 years, Hydrocortisone 11.0 ± 5.0 mg/m² initiated at age 9.7 ± 4.0 years
- Mean age at diagnosis 9.7 ± 4.4 years; mean follow-up 10.9 ± 6.3 years
- Hydrocortisone 11.0 ± 5.0 mg/m² initiated at age 9.7 ± 4.0 years
Main finding
As reported in the abstract
AHt-SDS vs Ht-SDS at diagnosis
−0.8 ± 1.0 vs. +0.2 ± 1.3
p < 0.001
AHt shorter than THt
−0.3 SDS
p < 0.001
Observational data: associations, not effects.
Further findings
Height, weight and BMI-SDS at last visit, glucocorticoid-treated (n = 92) vs never treated (n = 17)
- Similar between treated and never-treated patients
AHt by puberty timing (timely vs CPP/EP) and GnRH analogue
- AHt comparable between timely puberty and CPP/EP, no difference with or without GnRH analogue
AHt by pubertal status at diagnosis (Tanner 5, Tanner 1, Tanner 2-4)
- AHt Tanner 5, Tanner 1, Tanner 2-4
- 158.0 ± 7.6, 158.1 ± 6.1, and 157.5 ± 6.5; p = 0.9
Correlations of AHt-SDS
- THt
- R = 0.67, p < 0.001
- Ht-SDS at diagnosis
- R = 0.7, p < 0.001
- Age at diagnosis
- R = −0.05, p = 0.6
- Bone age advancement
- R = −0.04, p = 0.72
- Glucocorticoid treatment duration
- R = −0.11, p = 0.34
- Glucocorticoid dose
- R = −0.04, p = 0.70
Bone age advancement, CPP/EP (n = 43) vs timely puberty
- Bone age more advanced in CPP/EP than timely puberty
Original publication
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